Susceptibility of goats to poisoning by Tephrosia cinérea

ABSTRACT: Spontaneous and experimental poisoning by Tephrosia cinerea in the northeastern semiarid region of Brazil has only been described sheep. Pathologically, such leads to ascites centrilobular liver fibrosis. However, these effects require an study goats. This aimed determine goats’ susceptibility ingestion T. minimum toxic dose, describing main clinical anatomopathological findings. Poisoning was reproduced experimentally one sheep that received 10g/kg ground plant two goats, first receiving a dose 5g/kg second plant. The presented abdominal distension 34 days after beginning plant, developing sternal decubitus, breathing difficulty, opisthotonos, mandibular trismus, salivation, dysphagia, vocalization, pedaling movements on 50th day experiment. Fluid accumulation observed cavity via necropsy, with irregular, slightly whitish capsular surface. Histologically, lesions were moderate fibrosis, marked sinusoidal distension, accompanied hemorrhage, sometimes forming bridges between regions, associated dissociation hepatocyte cords. There discrete Alzheimer’s type II astrocytes gray matter occipital cortex nervous system. Goat 2 showed apathy, drowsiness, weight loss; 62th day, lateral decubitus evolved rotation neck towards flank. At edema face dewlap, slight liquid; yellowish material cavity. blackened areas surface liver. mild fibrosis cords vacuolar degeneration cytoplasm. 1 no signs; at multifocal diffuse intracytoplasmic hepatocytes detected. picture findings differ species, proving lower goats (compared sheep), differences pathogenesis epidemiological aspects poisoning.